The swellings in head and neck regions are not only common but are also challenging lesions when fine needle aspiration cytology (FNAC) is concerned. This study was conducted in Department of PathologyM.P.Shah medical college, Jamnagar over a period of two years to corroborate the FNAC findings of various head and neck lesions with histopathological examination.A total of 696 case were examined.Lymphnode lesions were the most commonly aspirated(55.03%) followed by thyroid (27.44%).Most common diagnoses were inflammatory(46.26%) followed by benign(30.89%) and malignant(17.96%), histopathological diagnosis were available for 127 cases(18.24%).This study illustrates the importance of FNAC as a primary and effective diagnostic tool in lesions of head and neck region.