Background: Neonatal period constitutes first 4 weeks of extra uterine life. Mucocutaneous manifestation of neonates ranges from mild self limiting conditions to life threatening dermatoses. Though most of the skin lesions are harmless, cutaneous lesions in a neonate will cause significant stress and anxiety to the parents leading to consult various specialists. Aim of the Study: To compare different dermatological manifestations in babies delivered by normal labour and other modes of delivery. Materials and Methods: It was a cross sectional study conducted in Department of Dermatology in a tertiary centre, Chengalpattu for the period of one year. Babies delivered in Obstetrics Department by various modes of delivery and neonates attending the outpatient department for skin manifestations were taken into study. A total of 231 babies delivered by normal vaginal delivery having skin manifestations were compared with 229 babies delivered by other modes with skin manifestations. From the collected information we looked for any statistical difference between the two groups. After getting the informed consent from the parents babies were examined for any skin manifestations and the findings were recorded. Diagnosis was arrived by clinical features and investigations like 10 % potassium hydroxide mount, Wright’s stain, Gram’s stain, bacterial culture and ultrasound. The statistical analysis was carried out using statistical software SPSS 19.0.  Observation and Results: Following observations were found in our study. Total number of neonates with skin manifestations was 460. Among 460 neonates 231 (50.2%) neonates were delivered vaginally, 220 (47.8%) delivered by caesarean section and 9 (2%) neonates delivered by forceps. In our study 255 (55.4%) neonates were male and 205 (44.6%) neonates were females. The most common dermatoses observed were Mongolian spots, Sebaceous hyperplasia and Erythema Toxicum Neonatarum. Rare cases such as aplasia cutis, collodion baby and giant melanocytic nevus were also documented in our study.  Most common lesions seen in neonates delivered by labor naturalis were sebaceous hyperplasia, milia, scrotal hyperpigmentation, irritant contact dermatitis and miliaria.. Most frequent lesions seen in other modes of delivery were Erythema Toxicum Neonatarum, Mongolian spot and physiological desquamation. Conclusion: Neonatal cutaneous manifestations are influenced by environmental factor, maternal and neonatal factors. Most of the skin lesions in newborn do not need any treatment and it is self limiting. Reassuring the parents in case of physiological lesion relieves the anxiety and prevents the parents from visiting various doctors.