Melioidosis is a disease caused by Burkholderia pseudomallei restricted to South East Asia and Northern Australia. Occasionally cases are reported from India and China. Recently a good number of cases have been reported from Manipal, Vellore and the Union Territory of Pondicherry particularly within the last 3 years.The important risk factors are uncontrolled Diabetes mellitus, Alcoholism and Chronic Kidney disease. Pneumonia is the commonest clinical presentation spread from the lungs or skin in debilitated individuals gives rise to septicemic forms of melioidosis, that carry a high mortality. Burkholderia pseudomallei is a saprophytic bacteria found deep in the soil and water. Humans and animals are infected by percutaneous inoculation, inhalation and ingestion. Here we report 4 cases of melioidosis  confirmed by culture with Dept. of Microbiology at Govt. Medical College, Thiruvananthapuram within a period of 6 months from April 2016 to September 2016. Two cases presented with pneumonia, one case with Breast Abscess and one case with septicemia. Burkholderia pseudomallei was isolated from samples of sputum, pus and blood in these patients. The cases with pneumonia and breast abscess survived. The patient with septicemia was a case of Chronic liver disease admitted with fever. Burkholderia pseudomallei was isolated from 2 blood samples with same antibiotic sensitivity pattern. In spite of treatment with Meropenem the patient expired on the next day. The mortality rate in bacteremia due to this organism i.e. reported to be 100% in various studies.