IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-6-5-10877 Original Research Paper Study of amplitude of accommodation in patient with Human Immunodeficiency Virus Mishra Dr. Dr Jyoti Landge Dr. May 2017 6 5 01 02 ABSTRACT

 Introduction: Human Immunodeficiency Virus [HIV] is known to cause premature ageing leading to reduction in amplitude of accommodation It is associated with many other  ocular and systemic diseases. Aim: The primary objective was to find out if HIV–positive patients have significantly reduced amplitude of accommodation compared with controls. The secondary objective was to investigate accommodative impairment in relation to factors such as age and CD4 count . Method: It was a cross sectional, open and prospective single center study in a tertiary care hospital in Western Maharashtra.It involved 200 HIV–positive patients aged from 35 years to 45years with no previous history of eye problems and 200 age–matched controls. Results :Blur reported by  HIV patients using  Royal Air Force [RAF] ruler for 35– 39 years age group was 9.01% [11/122] while for control group it was 2.08%[2/96], [p value <0.001]Reduced amplitude of accommodation below age expected norms was also observed. For age group 40–45 years , reduction in amplitude of accommodation  found for HIV patients and control was 96.15% and 95.09% respectively, [p Value <0.001]Accommodation failure was  not related to CD4 count  . Conclusion : This study has identified accommodative failure in a   significant proportion of HIV–positive patients aged between 35and 45years. This problem may be under–recognized. The need for near correction for the pre presbyopic age is often overlooked. Accommodation failure was not related to CD4 count .