Prolonged exposure to cigarette smoke injures the respiratory system causing pulmonary diseases such as chronic obstructive pulmonary disease (COPD). Oxidants damage the lung tissue decrease the pulmonary function and cause tissue hypoxia .Serum uric acid, the purine degradation  product  is elevated in various clinical conditions associated with hypoxia. This study was done to measure serum uric acid levels in chronic obstructive pulmonary disease patients. 55 stable patients with COPD, without comorbid conditions, were included as cases. 37 age and sex matched individuals were included as controls. Clinical, functional characteristics and serum UA levels were compared between cases and controls. Student’s unpaired t test was used to compare serum uric acid levels in cases and controls. The serum uric acid levels were significantly higher in patients with COPD than in controls.