The traditional therapy consisting of mechanical debridement may fail to eliminate the pathogenic bacteria because of their location within the gingival tissues or in other area inaccessible to periodontal instruments. This may lead to recurrence of periodontal inflammation. Systemic treatment with broad spectrum antibiotics has often been used as an adjunct to conventional treatment. To obtain an effective concentration of the antimicrobial drug in the periodontal pocket after systemic administration, repeated intakes over a prolonged period of time are required. Hence an attempt is made to study the effect of local delivery of these agents in periodontal pockets.