Background and objectives: Periodontitis results from an interplay between reactive oxygen species and antioxidants.  The present study explores the possibility of using uric acid as a biochemical marker for periodontal disease. Material and methods: 120 subjects were divided into 4 groups of 30 each of healthy, chronic periodontitis, smokers with chronic periodontitis and smokeless tobacco users with chronic periodontitis whose serum samples were collected and analyzed for uric acid. Values obtained were subjected to ANOVA and Post hoc test. Results: Uric acid levels were found to be significantly lower in chronic periodontitis compared to healthy subjects. While tobacco usage was found to increase uric acid levels. Conclusions: Serum uric acid level can be helpful estimator of oxidative stress produced by  tobacco usage and periodontitis.