BACKGROUND OF THE STUDY: In sudden death situations prompt and high quality ACLS is vital for patient survival. This can only be achieved by ensuring that nurses, and by extension, other health care professionals acquire the requisite ACLS knowledge and skills through training. OBJECTIVES:  1)To assess the existing knowledge and knowledge of practice among staff nurses regarding advanced cardiac life support before and after STP.2) To evaluate the effectiveness of STP regarding advanced cardiac life support among staff nurses.3) To find an association between the selected demographic variables of staff nurses and post test knowledge and knowledge of practice. MATERIAL METHODS: The study was conducted on 59 staff nurses at Krishna Hospital, Karad. Descriptive evaluatory approach was considered. Quasi experimental. One group pre–test post–test Study design was used; purposive random sampling technique was used. The instrument used for data collection was a Questionnaire on knowledge and knowledge of practice. RESULTS: Study concludes that majority of nursing staff having 30 (50.84%) good knowledge and majority of having 29(49.15%) average knowledge of practice regarding ACLS, There was no significant association found between knowledge among staff nurses with socio–demographic variable and there was no significant association found between knowledge of practice among staff nurses with age, gender and experience except education. CONCLUSION: Study concludes that Krishna hospital nursing staff having good knowledge and average knowledge of practice regarding ACLS after STP.thus, the STP was effective.