Clefts of the lip and palate are the most prevalent congenital craniofacial birth defects in humans. The developing field of tissue engineering is considered for the management of clefts of the lip and palate along with wide bony defects in surgical orthognathic cases. Although the current approaches for the treatment of the cleft of the lip and palate include surgery and bone grafts; however, there are limitations associated with these therapies. Tissue engineering strategies particularly, alveolar bone engineering and soft tissue engineering, may provide clinicians with new alternatives. A tissue engineering approach may be a useful alternative for the treatment of cleft palates as it mitigates the concerns of donor site morbidity as well as provides additional options of growth factors delivery.