In the present study catecholaminergic neurotoxin MPTP was used to lesion dopaminergic pathways in the experimental animal model of Parkinson’s disease (PD). The main objective of the study was to evaluate the effect of Clitorea ternatea (CT) on biomarkeres of Parkinson’s disease in mice. Swiss albino mice (adult male) were divided into control group, MPTP–treated group (30 mg/kg body weight, i.p in 0.9% saline, single dose), CTE treated groups (200 and 400 mg/kg body weight) after MPTP exposure for 21 days. Striatal total antioxidant capacity (TAC), serum and striatal xanthine oxidase (XO) activity, the marker of oxidative stress, and the DNA repair enzyme PARP (poly(ADP–ribose)polymerase) were estimated. There was a significant increase (p<0.05) in XO and PARP activities and a significant decrease (p<0.05) in TAC with MPTP treatment. CT treatment significantly (p<0.05) reduced these changes showing a significant neuronal protection. MPTP–challenged mice treated with 200 and 400 mg/kg of CT indicated significant neuronal protection by decreasing the XO and PARP activities. MPTP challenged mice treated with CT restored the TAC level significantly (p<0.05). Comparatively CT treatment at higher dose (400 mg/kg) was more effective in neuronal protection as indicated by biochemical parameters. In conclusion, CT extract enriched with bioflavonoids showed a significant neuroprotective effect against MPTP–induced neurotoxicity in mice by decreasing XO and PARP activities in and increasing TAC activity.