Background: Prevention  and treatment of drug resistance TB are major concerns before the Government and Health workers all together. To evaluate the various measures and TB control programs undertaken by the government agencies, regular surveillance of prevalence and incidence of drug–resistant TB is carried out. Objectives: The objectives of this research works was to find out if any difference between prevalence of  drug susceptible and drug resistant TB in different age groups of male and female patients exists. Materials and Methods: 750 Smear positive sputum samples in 2008 and 427 smear positive sputum samples in 2015 were processed for drug susceptibility testings using proportion method and data was tabulated age–wise and gender–wise. Results: During 2008, the proportions of drug resistance to any single anti–tuberculosis drug in male and female patients of all age–groups were 24.18% and 35.0% respectively. The proportion of MDR–TB in male and female patients of all age–groups were recorded as 22.00% and 30.50% respectively during 2008.           During 2015, the proportions of drug resistance to any single anti–tuberculosis drug in male and female patients were 20.20% and 20.74% respectively.  The proportion of MDR–TB in male patients during 2015 was recorded as 13.01% whereas, in female patients of all age–groups, it was recorded as 19.25% Conclusions: Prevalence of drug–resistance to anti–tuberculosis drug is more in female patients than in male patients, in 2008 and 2015.