Cirrhosis of the liver is a growing health problem in India and death from this condition is increasing rapidly among both men and women. Cirrhosis is a chronic disease of the liver in which diffuse destruction and regeneration of hepatic parenchymal cells, and diffuses increase in connective tissue result in disorganization of the lobular architecture. My aim was to determine levels of serum lipid profile in patients with liver cirrhosis. All the four variables (HDL–c, LDL–c, total cholesterol and TG) were significantly lower in cirrhotic patients than in the control group. There was a significant correlation between decrease in serum total cholesterol, HDL–c and LDL cholesterol level.