Introduction: Celiac disease is an immune mediated enteropathy characterised by gluten hypersensitivity. Sickle cell trait is autosomal codominant haemoglobinopathy due to mutation of gene for beta globin chain.   Case report: Here we are reporting a case of middle age female patient of refractory microcytic hypochromic nutritional anaemia with Sickle cell trait and coeliac disease occurring concurrently. Patient was diagnosed as having iron, folate and vitamin B12 deficiency anaemia which was not responding to supplementation of oral or intravenous iron, folate and vitamin B12, and thus on further subjecting to haemoglobin electrophoresis and serum Anti Tissue Tansglutaminase antibody was diagnosed to have Sickle cell trait and celiac disease. And patient responded well to gluten free diet with improvement in Haemoglobin.   Conclusion: Physicians should always be on a look out for commonly prevalent yet less diagnosed malabsorption disorders like celiac disease and haemoglobinopathies like Sickle cell trait in cases of Nutritional anaemias not responding to supplements and thereby improve quality of life of such patients by simple restriction of gluten in diet and simultaneously avoid inadvertent use of haematinics causing toxicity.