Now–a–days most of the cholecystectomy are done laproscopically. Laproscopic surgeries has many advantages like cosmetically better, less postoperative pain, faster recovery, less hospital stay[1]. But, creation of pneumoperitoneum results in many haemodynamic changes like rise in heart rate, systemic vascular resistance, pulmonary vascular resistance and decrease in cardiac output. Reverse trendelenburg position during surgery further decreases cardiac output.[2] Stimulation of sympathetic nervous system due to hypercapnia and pneumoperitoneum leads to catecholamine particularly norepinephrine and vasopressin release.