The term neurofibromatosis (NF) is used for a group of genetic disorders that primarily affect the cell growth of neural tissues. It is broadly divided into two categories: (a) von Recklinghausen‘s neurofibromatosis or NF–1, (b) bilateral acoustic neuroma or NF–2. Neurofibromatosis type 1 (NF1) is the most common type of NF, and accounts for about 90% of all cases. It is one of the most frequent human genetic diseases, with a prevalence of one case in 3,000 births. The expressivity of NF1 is extremely variable, with manifestations ranging from mild lesions to several complications and functional impairment. We describe three cases of neurofibromatosis type 1 in a family. The aim of this article is to report the NF1 in a family with different manifestations and to review the literature.