Aims: The aim of present study was to compare the lipid profile and biochemical values among patients of chronic renal failure (CRF) needing haemodialysis and patients of CRF being treated conservatively. Materials and Methods: This cross sectional, observational study consisted of consenting patients of CRF admitted or from out patients department. Socio demographic data and fasting blood was collected for biochemical, hematological testing and lipid profile. Results: For a total sample of 60 CRF patients 39 (65%)  (mean age 59.48 ± 15.37 years) patients were on conservative treatment and 21 (35%) (mean age 54.00 ± 13.83 years) who were on hemodialysis. The mean serum creatinine was 4.92 ± 2.79 and 8.37 ± 3.20 respectively for conservative and hemodialysis groups (t= –4.339, df= 58, p=.000). Also mean hemoglobin was 9.81 ± 2.48 gm% and 8.35 ± 1.91 gm% respectively for conservative and hemodialysis groups (t= 2.335, df= 58, p=.023)   Conclusions: This study finds a significantly elevated serum creatinine and decreased hemoglobin among CRF requiring hemodialysis in comparison to patients being treated conservatively.