Rheumatoid arthritis (RA) is a common autoimmune disease estimated to affect roughly 1% of the global population. Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects about 1.5% of the population. It is driven by multiple pathophysiological factors and manifests with high heterogeneity both among and within patients along the disease course.  Rheumatoid arthritis causes significant loss in work productivity, with up to one–third of those diagnosed unable to work within two years of the onset of RA.   Traditional methods of diagnosing RA rely both on a physical examination and on blood markers that differentiate RA from other autoimmune connective tissue diseases. ,  The diagnosis of RA is established primarily on clinical criteria and serologic findings. Hist