Aims and objectives: Staphylococcus aureus is the most common pus forming organism worldwide. It is more commonly present in nasal passage and skin, it is mostly responsible for nosocomial and post–operative infection. Now–a–days this organism developed resistance to many antibiotics and in hospital “hospital strains” is responsible for mortality. Materials and methods: Samples were collected in our K P C Medical College & Hospital from 7531 patients having diabetic foot, abscess, postoperative infection, and chronic otitis media during the year 2009 to 2016 December and sent to our bacteriology department for culture–sensitivity testing. The data was collected and analyzed extensively with the help of Statistical Package for the Social Sciences (SPSS) version 17. Results: Data demonstrated that 291 were staphylococcus aureus (162 were methicillin sensitive staphylococcus aureus (MSSA), 74 were methicillin resistant staphylococcus aureus (MRSA) and 55 CoNS (Coagulase negative staphylococcus aureus). In all groups of staphylococci males were significantly affected as compared to females (p=0.00). MRSA was highly (>90%) sensitive to teicoplanin, linazolid and vancomycin, MSSA to linazolid and teicoplanin and CoNS to vancomycin and teicoplanin. MSSA was > 70% to <90% sensitive to piperacillin–tazobactam, aminoglycoside group except Tobramycin, tetracycline and tigicycline, MRSA to netilmicin, amikacin and clindamycin and CoNS to chloramphenicol, tetracycline and linazolid. All the strains were nearly hundred percent resistance to polymyxin B and colistin, mild sensitive to semi synthetic penicillin and all generations of cephalosporins. Conclusions: This high degree of resistance is the result of extensive, illogical and inadvertent use of different antibiotics. So our aim to use the antibiotics very cautiously to prevent the development of resistance as well as to prevent the development of bacteria resistant to many commonly used antibiotics.