Introduction– Gall bladder  is  the organ that stores and concentrate the bile helps in the digestion of fat .It  gets affected by a variety of pathological processes.It ha s a wide spectrum of diseases ranging from congenital anomalies ,gallstones and its complications,non inflammatory,inflammatory to neoplastic lesions. Aim– To study the various histopathological; lesions involving the gall bladder. Materials and Methods–This was a prospective study of 1 year from January 2016 to December 2016,in the department of pathology,GMC jammu. H&E stained sections were examined microscopically. Result– A total of 800 specimens were received during the study period .The age of the patients ranged from 8 years to 80 years with a mean age of 42 years.Peak age incidence was seen between 30 to 40 years with 220 cases(27.5%) recorded during the decade.Male to female ratio ranged from 1: 4.Females 600 cases were more common than males 200 cases. Most common histopathological spectrum seen was chronic cholecystitis  643 cases(80.4%)  .   Out of  which  351  cases  were found to be associated with cholilithiasis . Other lesion were Metaplasia including pyloric gland metaplasia and intestinal metaplasia 64(8%) cases , cholesterosis43(5.3% ) cases, Xanthogranulomatous cholecystitis48(6%) cases, Acute cholecystitis1case (0.25 %),   Adenocarcinoma 1 case(0.25%). Most of the patients (90% ) presented with history of pain right hypochondrium followed by dyspepsia and non specific symptoms. Conclusion –Chronic cholecystitis is the most common histological entity.Association with stones is seen in majority of patients resulting into variety of mucosal alterations and lesions