Background To assess the result of local control (LC) and survival in patients with unfavorable T2N0 glottic cancer who were treated with radiotherapy with or without chemotherapy.   Methods Forty seven patients with unfavorable T2N0 glottic cancer treated between 2005 and 2012 were analyzed retrospectively. Prognostic factors were evaluated by univariate analysis.   Result The 5–year LC rate of all patients was 70%. In univariate analysis 5–year LC rate of all patients treated with chemo radiation was 93.1% and only radiation was 54.1% which was statistically significant. The 5 year OS rate of all patients was 75% of these treated with chemoradiation was 93.1% and only radiation was 62.5%.   Conclusion The retrospective analysis shows that a high rate of local control in patients with unfavorable T2N0 glottic cancer treated with chemoradiation when compared to radiotherapy alone.