AIM: To determine the etiological factors prevalent in and around Secunderabad contributing to non– traumatic paraplegia.   To study the clinical pattern of evolution and presentation of nontraumatic paraplegia.The etiological subcategorization of various non–traumatic paraplegia.   BACKGROUND :  Non traumatic paraplegia, although make up significant percentage of hospital admission incidence, clinical presentation and etiology have not been well studied. A better understanding of these issues will assist in the medical management and rehabilitation.    OBJECTIVE : This study aimed to identify the clinical profile and etiologies associated with non traumatic paraplegia. MATERIAL METHODS :30 patients of non traumatic paraplegia were studied at Gandhi General Hospital. Patients underwent a detailed clinical evaluation followed by laboratory investigations and neuroimaging studies •       Non –traumatic  paraplegia is commonly seen in males than females,mode of onset is acute in 42%,sub–acute in 30%and chronic in 27%  All 30 patients (100%) presented with weakness of lower limbs,57% had  retention of urine,23% backache,23%incontinence of urine,17% fever,3% tingling and numbness. •       INTERPRETATION AND CONCLUSION: •       Non–traumatic paraplegia is commonly seen  in between  21–40 years of age,more in males. The  commonest cause of non–taumatic paraplegia is tranverse myelitis 60%,followed by tuberculosis of spine– 20%,sub– acute combined degeneration –7%,HIV myelitis– 3%,hereditary spastic paraplegia –3%,disc prolapse –3%,spinal neoplasm –3%.