Pain can develop due to various stimuli. Analgesics are the drugs used to reduce the pain in various disorders. Analgesic activity of Venlafaxine was screened in the present study. Swiss Albino mice were used in the study. Tail clip and flick models were used to screen analgesic effect of Venlafaxine. Mice pretreated with Aspirin and Venlafaxine showed significant analgesic effect compared to control group. Venlafaxine showed lesser analgesic effect compared to Aspirin. In conclusion Venlafaxine showed significant analgesic effect in both models. Further studies are required to screen analgesic effect of Venlafaxine in different models and animals.