Ameloblastoma is Benign Epithelial Tumor which is a slow growing and locally invasive and the second most common odontogenic neoplasm of concern. Ameloblastomas are differentiated into unicystic intraosseus, multicystic, solid intraosseus or peripheral types. The term Unicystic Ameloblastoma (UA) refers to those cystic lesions that show clinical, radiographic or gross features of jaw cyst but on histologic examination which shows typical ameloblastomatous epithelial lining of cystic cavity with or without luminal tumor growth. In the present retrospective study an attempt has been made for the histological Correlation of UAs with Biological profile of 34 Cases in Indo–Dravidian Population.