Fixed dose drug combination (FDC) of amlodipine and atenolol are being prescribed extensively for the management of hypertension and chronic stable angina. The poisoning of calcium channel blocker along with a beta blocker is a nightmare in clinical settings due to  potentially life threatening complications, especially, profound refractory bradycardia and persistent hypotension. Lack of treatment guidelines further adds to already challenging clinical scenario. Treatment can be done with fluid, calcium, and beta adrenoceptor agonists or with hyperinsulinemia and euglycemic as adjunctive therapy. The literature available on management of Amlodipine plus atenolol overdose is scarce. The authors present a case of 50 year old female patient who was presented in the emergency department after she had allegedly consumed a bottle of FDC tablets of amlodipine and atenolol. The authors reviews the literature and discusses treatment options available for the management.