This study evaluates the value of residual tumor burden scoring in patients who have received neoadjuvant chemotherapy followed by mastectomy in locally advanced breast carcinoma.  The average  age of  presentation with breast cancer was 51.7 years.Partial response after neoadjuvant chemotherapy was seen in 10% and 40% of patients with RCB score1and 2 respectively.48% of patients exhibited a RCB score 3 .Complete response was seen in 2% of patients. There was a strong correlation between ER AND PR .Subjects with ER positive have a higher probability of being PR positive.Subjects with Her 2neu positive and ER negative have a higher probability of chemoresistance .