Aims and objectives: Klebsiella pneumoniae, one of the commonest form of gram negative bacilli responsible for respiratory tract infection in hospitalized patients. Now–a–days due to increased and non–selective use of antibiotics in chambers, primary health center and corporate hospitals there is emergence of multi–drug–resistant organism. As a result mortality of the patients infected with klebsiella pneumoniae has been increased enormously. So the aim of this present study was to demonstrate the spectrum of antimicrobial sensitivity of klebsiella from the sputum sample in the local community. Material and methods: From 1078 patient suffering from chest infection in K P C Medical College sputum were collected and cultured in different media. From these isolates different recent biochemical tests were carried out to confirm this particular organism. After confirmation these isolates were inoculated into plates containing different antibiotics. Results: Among total collection of 1078 samples of sputum, 216 were non– extended spectrum beta–lactamase (non–ESBL) (males=135, females=81) and 96 were extended spectrum beta–lactamase (ESBL) klebsiella (males=65, females=31). Non–ESBL klebsiella were highly sensitive to polymyxin B and colistin, moderately sensitive to imipenem and meropenem (>80% but <90%) whereas, ESBL producing klebsiella were 60% to 70% sensitive to the above antibiotics. Most of the penicillin, cephalosporin groups, aminoglycoside groups, vancomycin, linazolid, clindamycin and teicoplanin demonstrated nearly hundred percent to nearly 60% resistance to this organism. Conclusion: This study demonstrated the emergence of multidrug resistant klebsiella in this community which will be very harmful for the local community. So, our aim should be to make a proper antibiotic use policies and proper preparation of spectrum of antimicrobial sensitivity, so that the patient will receive proper antibiotics and thus emergence of multi–drug–resistant klebsiella can be prevented.