We describe multiple Giant cell granulomas in a 17–year–old female who has presented in three months back with a large central giant cell granuloma of the right mandible with a history of trauma and she was treated with a surgical enucleation. A small recurrence was then identified on left maxilla (24, 25 region) after total extraction of teeth and the lesion was surgically excised and histologically confirmed as Peripheral giant cell granuloma with successful management and further referred for prosthesis. It is possible that the present case may indeed represent a new syndrome or subtype of multiple giant cell granulomas. The problem of treating such giant cell granulomas within a short period is also addressed in the context of recent advances of surgical and medical management.