Autogenic breathing cycle technique was compared to the usual treatment of postural drainage for mucociliary clearance in cystic fibrosis or bronchiectasis. An evidence based medicine review was performed. Autogenic drainage has the advantage of being performed in a seating position, whereas postural drainage is performed lying in a head down position with the assistance of a caregiver. Results showed only low levels of evidence to support the advantage of autogenic breathing cycle technique over postural drainage.