Objective: To study epidemiology & clinical profile of Gestational Trophoblastic Disease and to evaluate its management and outcome. Method: It was a prospective observational study of women (50 cases) with molar pregnancy who were diagnosed, treated and followed up at Umaid hospital, Jodhpur, Rajasthan from 1^st July 2012 to 31^st July 2013. Results: Incidence of Gestational Trophoblastic Disease was 1.76 per 1000 pregnancies with mean age distribution of 24.68 years and was found to be most frequent in nulliparous women with low socioeconomic status presenting with amenorrhoea followed by vaginal bleeding. After primary treatment, during follow up all cases were cured including malignant ones. Conclusion: Gestational Trophoblastic Disease requires early diagnosis, treatment and strict monitoring to be 100% curable.