Psychological symptoms and Health Related Quality of Life (Hr‐QoL) in Ischemic Heart Disease (IHD) are relatively less explored in our country. This cross‐sectional study was undertaken to assess the common psychological symptoms experienced by patients with IHD and to gain an impression on Health related quality of life in patients with IHD. Thirty patients with IHD were evaluated for psychological symptoms using DASS. Quality of life was assessed using Ferran’s Hr–QOL questionnaire. The data were analyzed using SPSS v 16.0 software. 73.3% (n=22) participants rated themselves to have clinical level of depression, 63.3% (n=19) experienced significant level of stress and 76.7 % (n=26) reported to have significant level of anxiety symptoms. 23.3% (n=7) of the participants reported to have very poor quality of life, whereas 30% (n=9) reported to have better quality of life even though having illness. There was no significant difference in psychological symptoms and quality of life across participants of both gender. Further it was found that the quality of life was not significantly related to severity of psychological symptoms experienced by the participants. The findings of our study reveal a high rate of psychiatric morbidity and impaired quality of life in IHD Patients.