Cancer of unknown primary (CUP) is defined as a heterogeneous group of malignancies presenting as lymph node or distant metastases, for which a workup fails to identify the site of origin. This is a diagnostic and therapeutic dilemma to the clinician. The work up has to be done by a careful stepwise protocol. It is source of severe mental and the physical anguish to the patient and the economic impact is high. Thereby arises the need for oral oncologist to reflect upon how much of investigation is necessary to detect the elusive primary. We report a case of a 67 year old male patient with cervical node metastases from an unknown primary with a discussion on the necessary workup to detect the unknown primary.