Lower respiratory tract infections are the major cause of death from infectious disease, even in modern antibiotic era. The emergence of multidrug resistance among organisms is an issue of increasing concern. The study was conducted with the aim of identification of respiratory pathogens and their antibiogram. Lower respiratory secretions (sputum, pleural fluid, bronchoalveolar lavage) of 400 patients over one year were cultured, identified and antimicrobial susceptibility was performed by standard methods. Out of these, 244 were culture positive. Most prevalent pathogen was Klebsiella pneumoniae. Sensitivity of the gram negative and gram positive isolates were performed to find out most effective drug by in vitro tests.