Cholecystectomy is among the commonest operations in general surgical practice. Laparoscopic cholecystectomy is the gold standard for treatment of cholelithiasis. There are many techniques used for ligation of cystic duct in laparoscopic cholecystectomy at present with their advantages and disadvantages. In this study I used thread as a ligating material for cystic duct. The study was done in Tapaswi Hospital, Bhagalpur, Bihar with total number of patients in my study were 1500 from January 2012 to December 2016. Routine investigations were done before posting for operation. The study group included both males and females. The Results of the study showed that cystic duct ligation with thread is practical, safe and cost effective as compared to use of clips.