IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-6-7-11475 Original Research Paper SIGNIFICANCE OF VARIOUS BIOCHEMICAL MARKERS TO ASSESS SEVERITY OF HYPERTENSIVE DISORDERS OF PREGNANCY Manpreet Kaur Dhillon Dr. July 2017 6 7 01 02 ABSTRACT

 Hypertensive disorders of pregnancy or Pregnancy induced hypertension (PIH) is a common gestational disorder which  is associated with maternal and fetal morbidity and mortality .Yet the etiology of this disorder is little understood. Alterations in levels of  liver function  and renal function markers have been suggested to be linked to severity of  PIH. Present study aimed to  evaluate levels of various biochemical markers and their importance in assessing severity of PIH. Material and methods: 50 patients with PIH which constituted study group and  50 normotensive pregnant women constituted control group. Collected samples were analysed for uric acid , urea and creatinine levels which predict renal functions and liver transaminases (SGOT and SGPT) which predict liver functions. Result:  Serum Uric acid levels significantly increased  (p<0.001) , levels being  4.27±0.83mg/dl in normal pregnant women and 5.56 ± 0.78 mg/dl in PIH patients. There was no difference in levels of urea and creatinine among two groups. .The increase in SGOT   and SGPT levels in study group as compared to control group shows statistically significant association (p value= 0.008) .

Conclusion: Serum uric acid and liver transaminases are strongly associated with pre eclampsia, suggestive of their predictive role in assessing hepatorenal damage in patients presenting with pregnancy induced hypertension.