Chronic obstructive pulmonary disease subjects (COPD) is a disease characterized by persistent airflow limitations and is progressive in nature. Major factor related to prevalence of COPD is tobacco smoking. Indoor, outdoor and air pollutions are other factors.  

Objective:

The objective of present study is to investigate the role of paraoxonase 1 (PON 1) Arylesterase and Lactonase activities in COPD subjects.

Design:

The study group consists of 40, COPD and 40 healthy subjects as a control group. PON 1 arylesterase (PON 1 ARE) activity was measured by using phenylacetate as substrate and phenotyping was done by two substrates method. PON 1 Lactonase activity was estimated by using Dihydrocoumarine (DHC) as substrate.

Results:

PON 1 ARE and lactonase activities were found significantly lower in COPD subjects as compare to healthy controls (p<0.05).

Conclusion:

Significantly decreased PON 1 activities (ARE and lactonase) in COPD  subjects than in controls showed increased oxidative stress in COPD subjects.

Serum paraoxonase 1 (PON 1) arylesterase & lactonase activity in chronic obstructive pulmonary disease (COPD)