Background: Hyaluronic acid (Hyaluronan) is an extracellular constitute of the connective tissue acts as a barrier to plaque bacteria and maintains the health of gingival tissue. Recently, 0.2% Hyaluronic acid is introduced as an anti–inflammatory agent for topical application in the treatment of chronic gingivitis.

Aims: To evaluate the clinical efficacy of topically applied 0.2% Hyaluronic acid containing gel as an adjunct to scaling in plaque induced moderate to severe chronic gingivitis subjects.

Materials and Methods: 40 subjects of both gender; and ages ranging 18–35 years diagnosed with plaque–induced moderate to severe chronic gingivitis, were divided into two groups of 20 each: Test Group (scaling along with application of 0.2% hyaluronic acid) and Control Group (scaling alone). Plaque index (Silness and Loe 1964), gingival index (Loe and Silness, 1963), and sulcus bleeding index (Muhlemann and Son, 1971) of each subject were recorded at baseline, 2 and 4 weeks period.

Statistical analysis: Data was analysed using Student‘s unpaired‘t’ test.

Results: Intergroup comparison of the two treatment modalities revealed a statistically significant improvement in the clinical parameters for both groups at 4^th week. Mean reductions in Gingival Index score (GI) was 1.06 ± 0.35 (Test Group) and 0.76 ± 0.23 (Control Group), respectively and Sulcus Bleeding Index score (SBI) was 1.21 ± 0.26 and 0.97 ± 0.22, respectively, which were statistically significant (P≤0.05).

Conclusions: Topically applied 0.2 % Hyaluronic acid containing gel as an adjunct to scaling was more effective in treating plaque induced moderate to severe gingivitis than scaling alone.