A study to assess the knowledge regarding HIV/AIDS among primigravidae of selected hospital, Bhopal. A non–experimental research design was used. The 100 subjects of primigravidae were selected by using non probability convenient Sampling technique.   The study revealed that 82% had good Knowledge. 17% had average knowledge. 1% had poor knowledge. The association of knowledge with socio demographic variables were significant i.e. education, area of residence & information source of HIV/AIDS and non–significant were age of mother, religion, pregnancy in months during interview schedule.