Bone regeneration is a well orchestrated physiological process of bone formation which mimics the normal cascade of bone formation following fracture, involving the continuous bone remodelling throughout adult life. Currently, there is a surfeit availability of bone regeneration materials to augment the impaired or the insufficient bone by the use of autogenous, autologous, xenografts, alloplastic, osteoprogenitor cells and distraction osteogenesis. Improved bone regeneration therapies are in advent like gene therapy, tissue engineering and the systemic enhancement of bone repair. The periodontal regeneration associated with minimal invasive therapy preserves the dentition and supporting structures with minimal soft tissue trauma and the removal of granulation tissue from periodontal defects using a much smaller surgical incision than that used in standard bone graft techniques. The potential efficacy of Platelet rich fibrin (PRF), Decalcified freeze dried bone allograft (DFDBA) along with Modified Minimal invasive periodontal surgery (MIPS) has proved to be beneficial in bone regeneration.