Introduction:  Acute organophosphate poisoning is one of the commonest poisoning and has reached epidemic proportions in most parts of the world especially in developing countries where its management is lacking leading to high fatal outcome. Acute pancreatitis is one of the serious complications of this poisoning. This potentially fatal complication can be over looked in the absence of typical clinical features of acute pancreatitis.

Materials and methods: The objective is to determine the prevalence of acute pancreatitis following organophosphate poisoning. This was a retrospective analysis conducted at postgraduate department of medicine; Govt. Medical College Jammu. Patients of both sexes with age more than 16 years admitted with positive history of organophosphate poisoning (OP) were included in this study. A Performa was designed and all the collected data regarding basic information of the patients, past history, physical examination and relevant investigations like complete blood count, serum amylase and lipase, alanine amino transferase(ALT), ultrasound abdomen, CT abdomen( where needed) were recorded.

Results: Among 50 patients in our study group mean age was 40±9 years. Significant symptoms seen were muscarinic in the form of secretions (80%), pin point pupil (40%), respiratory failure (10%). Marked nicotinic symptoms seen were fasciculations (20%). Significantly elevated amylase (>300u/l) was seen in 50% (n=25) of patients out of which patients 18% (n=9) had significantly elevated lipase (>150) levels, confirmation of acute pancreatitis was done by ultrasonography of abdomen and CECT abdomen. The acute pancreatitis were seen in 18% (n=9) of patients and all were managed conservatively and discharged.

Conclusion: Elevated serum amylase and lipase levels are more frequently seen in organophosphate poisoning and can predict the diagnosis of acute pancreatitis as a complication, so that a proper management of such patients can be done.