Introduction– With increase in dynamic mechanism of life there is increase in primary fixation (internal/ external) of such fractures. Ultimately there is an increasing number of post operated osteomyelits. There are various modalities available to surgeon for treatment of chronic Osteomyelitis and infected non– union of long bones. We have used of Antibiotic impregnated, bone cement coated intra– medullary nail in this study. Materials and Methods– Fifty patients with chronic osteomyelitis and infective nonunion of long bone were included in the study. Thorough debridement and Intramedullary device with coating of antibiotic impregnated bone cement was put in the patient until infection was controlled. Result– Mean time to infection resolution was 6.5 weeks. Average hospital stay was 2.3 weeks after primary procedure. Patients were discharged on oral antibiotics and followed up in OPD till 2–3 weeks after discharge stopped. We found excellent result in 38 cases, good results in 6 cases, unsatisfactory result in 3 cases. 3 patients didn’t come for follow–up.