Staphylococcus aureus is the most common cause of hospital and community acquired infections. The increasing prevalence of Methicillin Resistant Staphylococcus aureus (MRSA) has led to the widespread us age of Vancomycin which in turn leads to the emergence of resistance to glycopeptides antibiotics.The health–care institutions face constant and evermore problems ,because of MRSA.   A Regular surveillance of hospital–associated infections is mandatory to Minimizing the emergence of this organism and its spread. Study concludes that implement appropriate diagnostic methodology for Isolating MRSA strains and also to ensure strict antibiotic policy in all the healthcare Institutions with precautionary measures before starting the patient on Vancomycin.