Prosthodontic rehabilitation of patients with acquired mandibular defect represents a difficult challenge for both the reconstructive surgeon and prosthodontist. Rehabilitation is an essential part of cancer care and should be consider from the time of diagnosis. Surgical resection often creates large defects. With continued evolution in the rehabilitation techniques, the prognosis for these patients has greatly improved. This article represents rehabilitation of a hemimandibulectomy patient who had undergone resection without reconstruction. The aim of this article is concentrated on improvement of retention, stability, esthetic and phonetic function of the patient so that she could live a normal productive life