Introduction– The prevalence of type 2 diabetes (T2DM) is increasing worldwide and exhibits a challenge on the health care system as well as on the public health. This Meta–analysis was done to determine relation between CRP and type 2 DM.

Material and Methods– We conducted the present meta–analysis in accordance with the (MOOSE) guidelines. Only prospective studies were included. Literature search was done using different databases. SPSS and Revman software were used for analysis.

Results– The concentration of CRP was found to be higher in diabetic patients as compared to non–diabetic participants. The combined risk ratio for diabetes comparing individuals in funnel plot, CRP distribution was 5.39 (95% CI 4.49–6.47), with substantial heterogeneity between studies.

Conclusion– The associations between CRP and type 2 diabetes appear to be stronger than previously reported, and that CRP may be an independent risk factor for type 2 diabetes.