To study the commonest clinical complication requiring admission of children with sickle cell disease.Indication of Blood Transfusion received by the patient.To assess the vaccination status which also includes special vaccines like Pneumococcal, Typhoid, Meningococcal along with universal immunisation programme vaccines. It was a retrospective case series study which was conducted at tertiary care hospital NKPSIMS and LMH, Nagpur from July 2013 to June 2014. The case records were analysed as per the pro forma. Total of 68 case records were studied of which 11 case records were excluded due to incomplete data. Total of 57 subjects were included in the study and data was analysed. Result– Fever (35%) constituted as a sole presentation for admission. The commonest indication for Blood Transfusion were Stroke (7%) and Severe Malaria (7%). No statistical significance was observed regarding blood transfusion in febrile patients. Only 10.5% of subjects were vaccinated with Pneumococcal vaccine and 28% of subjects were vaccinated by Typhoid vaccine. Conclusion: Even with the widespread availability of special vaccines for children with Sickle Cell Anemia, there is a need for awareness for the beneficiaries which can be achieved by utilising peripheral workers like Anganwadi & ASHA workers and also use of media in regional languages.