The history of cardiovascular system has its origin in ancient times when a papyri was found in Egypt which described the relationship between the heart and blood vessels. The description of blood circulation from autopsy techniques allowed to know that the blood flowed into the vessels. Firstly, the heart was described in separated cavities in Ancient Greece by Hipocrates. During the Roman empire, Claudius Galenius considered that the arteries carried distinct blood from the venous blood. Until the beginning of the Renaissance, the knowledge about the cardiovascular system was based mainly on assumptions. The paradigm shift between the past and the future came with the experimental models of Willian Harvey which presented the first accurate explanation of the the cardiac physiology.