A surgical challenge, that any thoracic surgeon can be exposed to, is transthoracic esophagectomy post pneumonectomy. It has been rarely described in the literature.

Herein, we report a case of a 68 year old female patient, with history of left lung adenocarcinoma treated by left pneumonectomy followed by chemotherapy and radiotherapy, admitted for surgical management of a second primary esophageal cancer by esophagectomy.