Background–our aim was to study the effectiveness of intravenous dexmedetomidine (1 ug/kg) in attenuation of haemodynamic response to laryngoscopy and endotracheal intubation.

Material and Method – study was conducted on 100  patients divided randomly into 2 groups{ each 50} comparable in demographic parameters. Group D Patients were given Inj Dexmedetomidine 1ug/kg IV diluted in 100 ml normal saline and administered over 20 min before induction & Group C  Patients were given intravenous 100 ml normal saline administered over 20 min before induction.

RESULT –there was significant reduction in heart rate, systolic blood pressure, diastolic blood pressure, mean blood pressure in group D as compared to group C at 0 minute, 5 minute & 10 minute after intubation.

Conclusion :

Dexmedetomidine at a dose of 1μg/kg body weight diluted in 100 ml Normal saline given over 20 minutes before induction significantly attenuates the

haemodynamic responses to laryngoscopy and endotracheal intubation.