Introduction: Fine needle aspiration cytology provides early diagnosis, evaluation, planning and institution of treatment. Most bone lesions are amenable to the FNAC procedure.

Objective: The aim of the study is to emphasize the usefulness of FNAC in the diagnosis of suspected bone lesions both benign and malignant, and compare it with clinico–radiological diagnosis and histopathology.

Results: Present study was conducted in 47 cases, sensitivity of FNAC in the diagnosis of bone lesions was found to be 74.46%, there were 35 true positive cases and 12 false negative cases. Greatest numbers of cases diagnosed correctly were of Giant cell tumor, followed by Metastatic tumor, Inflammatory lesions, Chondroma and Chondrosarcoma. Male : female is 2.35:1. Most cases in the age group of 21–30 years.

Conclusion: Cytopathology assessment with the clinical and radiology findings together can yield almost the same diagnostic accuracy in majority of lesions when compared with that of histopathology diagnosis.