This study reviews the demographic aspects and histomorphological changes that occur in the gall bladder.The present retrospective and prospective study was carried out in the Department of Pathology,Stanley Medical College,Chennai during a period of one year from August 2015 to August 2016.A total of 200 cases were examined and  parameters such as age and clinical presentation  were recorded in adjunct to the histopathological study of the  received  gall bladder.The age group ranged from 21yrs to 70yrs with a sex predilection towards females,the M:F ratio being 1:1.78.The most common lesion was chronic cholecystitis and the  spectrum of lesions in our study were, adenomyoma,empyema, granulomatous cholecystitis,cholesterolosis and adenocarcinoma .Hepatoid adenocarcinoma of the gall bladder was a rarity in this study.