The frequency of breast cancer is increasing. It is  second most common cancer in females. A number of lesions cause differential diagnostic dilemma at clinical and microscopic level. Aim of the study is to analyze the histomorphological spectrum of breast diseases. All biopsies, lumpectomies and mastectomies received during 2016 were included. Breast  specimens represented 5.77% of total specimens. 323 cases (75%) presented with lump. 23 (5.34%) were males and 407 (94.65%)  females with a sex ratio of 1:17.6. Benign lesions was the largest group 276  (64.18%) followed by malignant lesions 106 (24.65%). Benign and malignant lesions were most profound in 21–30 and 41–50 years respectively. Fibroadenoma 135 (31.39%) amongst benign and infiltrating duct carcinoma 96 (22.32%) amongst malignant were most common. Inflammatory lesions amounted to 48 (11.16%). Mastitis 30 (6.97%) cases was  most common amidst them . Few unusual  cases  also seen. Study showed a wide spectrum of lesions.